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raw powder 9-Methyl-9H-beta-carboline 9ME-BC

    • 1384 posts
    September 30, 2019 12:18 PM EDT
    up-regulates, differentiates and protects dopaminergic neurons,
    dendrities and synapses, especially in the substantia nigra of the
    midbrain and in the hippocampus [1">[2">[6">[7">

    - increases dopamine synthesis 9-Me-BC

    increases neurotrophins/neurotrophic factors (NGF, BDNF, CDNF [6">,
    GDNF, SHH [5">) and decrease apoptic signals [6"> (like caspase-3)

    - decreases inflammation, preventing microglia
    proliferation and chemokine release [4">, protecting against
    lipopolysaccharide toxicity [5"> and reducing LDH [2">[6">
    (lactate dehydrogenase) [7"> reduces α-synuclein [4">[5">, the
    aggregation of which form insoluble fibrils (like lewy bodies), one of
    the causes of some neurodegenerative disorders, like PD and AD
    (alzheimer's disease)

    - increase TH [6"> (tyrosine
    hydroxylase) expression and its transcription factors, and interacts
    with tyrosine kinases [4">[5">[7">. TH converts L-tyrosine to
    L-Dopa, needed for the synthesis of the catecholamines, especially

    - MAO-B inhibition [3">, preventing the formation of
    neurotoxic substances, like DOPAC (from the dopamine metabolization),
    6-OH-DA (oxydopamine), and MPDP⁺/MPP⁺ (from MPTP), the major cause of
    dopaminergic neurons death

    - increases/protects/recovers the NADH
    dehydrogenase (or "complex I" [6"> which catalyzes the transfer of
    electrons between NADH and Co-Q10), enhancing the mithocondrial
    respiration chain [7">